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KMID : 0357920130470020093
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Korean Journal of Pathology
2013 Volume.47 No. 2 p.93 ~ p.99
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Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics
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Toll Adam D.
Hruban Ralph H.
Ali Syed Z.
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Abstract
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Acinar cell carcinoma is a rare malignant epithelial neoplasm with predominantly exocrine acinar differentiation and is seen primarily in older men (mean age, 62 years). The presenting symptoms are usually non-specific, and jaundice is often not present. Symptoms relating to the overproduction and release of lipase into the circulation are present in 10-15% of patients. Characteristic cytomorphologic features include a population of cells with minimal pleomorphism, eccentrically placed nuclei with a single prominent nucleoli and moderate hyperchromasia. The cytoplasm is finely granular, and the background may contain granular debris secondary to cytolysis. A significant proportion of the cases also have a minor neuroendocrine component or scattered neuroendocrine cells. Approximately 50% of patients have metastatic disease at presentation, often restricted to the regional lymph nodes and liver. The prognosis is poor, only slightly better than that of pancreatic ductal adenocarcinoma.
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KEYWORD
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Carcinoma, acinar cell, Pancreas
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